Table 4 |
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|
The kinetic parameters for incorporation of the natural nucleotide (dAMP) and compound I into P1T1 by HIV-1 RT. |
|||
|
Vmax [nM.min-1] |
KM [μM] |
Vmax/KM [min-1] |
|
|
|
|||
|
dATP |
35 ± 2 |
0.3 ± 0.1 |
116 × 10-3 |
|
Compound I |
37 ± 5 |
447 ± 117 |
0.08 × 10-3 |
|
|
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|
[HIV-1 RT] = 0.025 U/μL, [P1T1] = 125 nM. |
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|
Song et al. Journal of Systems Chemistry 2011 2:3 doi:10.1186/1759-2208-2-3 |
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