Table 4 |
||
|
Assigned mean ± standard deviation values of Ka for the synthetic hosts used in the simulation and summary of binding constants for various interactions observed experimentally in biological systems as tabulated by Houk[50]. |
||
|
Host type |
Guest type |
Mean (log Ka) |
|
|
||
|
β-cyclodextrin |
Organic molecule |
4 ± 2 |
|
CB[6] |
Organic molecule |
6 ± 2 |
|
CB[7] |
Organic molecule |
8 ± 3 |
|
CB[8] |
Organic molecule |
8 ± 3 |
|
Catalytic antibody |
Transition state |
6.6 ± 2.0[50] |
|
Receptor |
Drug |
7.3 ± 1.5[50] |
|
Antibody |
Antigen |
8.1 ± 2.0[50] |
|
Enzyme |
Inhibitor |
8.6 ± 2.1[50] |
|
|
||
|
Ghosh et al. Journal of Systems Chemistry 2010 1:6 doi:10.1186/1759-2208-1-6 |
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