Table 3 |
||||||||
|
Asymmetric synthesis of pyrimidyl alkanol 2 without adding chiral substances by the addition of diisopropylzinc to pyrimidine-5-carbaldehyde 1 in the presence of N-methylmorpholine 5. |
||||||||
|
Run |
Pyrimidyl alkanol 2 |
Run |
Pyrimidyl alkanol 2 |
Run |
Pyrimidyl alkanol 2 |
|||
|
|
|
|
||||||
|
ee |
Config. |
ee |
Config. |
ee |
Config. |
|||
|
|
|
|
||||||
|
1 |
34 |
S |
8 |
15 |
R |
15 |
6 |
S |
|
2 |
37 |
R |
9 |
33 |
S |
16 |
9 |
R |
|
3 |
52 |
S |
10 |
7 |
R |
17 |
29 |
R |
|
4 |
33 |
S |
11 |
10 |
S |
18 |
12 |
S |
|
5 |
20 |
R |
12 |
6 |
S |
19 |
12 |
R |
|
6 |
16 |
R |
13 |
7 |
R |
20 |
27 |
S |
|
7 |
33 |
S |
14 |
7 |
S |
|||
|
|
||||||||
|
Suzuki et al. Journal of Systems Chemistry 2010 1:5 doi:10.1186/1759-2208-1-5 |
||||||||
